Radiation Dose and Cardiac Risk in Breast Cancer Treatment: An Analysis of Modern Radiotherapy Including Community Settings

Conclusions MHD varies substantially across patients and is influenced by technique in predominantly community settings. Overall risk of cardiac toxicity is modest. Summary We assessed mean heart dose of radiotherapy (RT), and estimated risk of RT-associated cardiac toxicity in women undergoing adjuvant RT for left-sided breast cancer in a large contemporary cohort. For 60-year old women without cardiovascular risk factors, the predicted excess risk of death from ischemic heart disease 20years post-radiation was 3.5 excess events/1000 patients, lower than estimates derived in prior studies (8 per 1000). Mean heart dose varied substantially and was influenced by technique. (Source: Practical Radiation Oncology)

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