Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery [Pharmacology]

Inadequate target exposure is a major cause of high attrition in drug discovery. Here, we show that a label-free method for quantifying the intracellular bioavailability (Fic) of drug molecules predicts drug access to intracellular targets and hence, pharmacological effect. We determined Fic in multiple cellular assays and cell types representing...

from ! Medicine by Alexandros G. Sfakianakis via als.fakia on Inoreader http://ift.tt/2v58IVU
via IFTTT