miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA).

Authors: Zheng B, Jeong S, Zhu Y, Chen L, Xia Q Abstract The microRNAs are a group of 20 nucleotides-long non-coding RNAs. By binding to the 3'UTR region of target mRNA, microRNAs can perform extensive actions mediating gene expression at post-trancriptional stages. It makes microRNAs serve as very crucial regulators in various biological progress including carcinogenesis. Long non-coding RNAs, however, are a subgroup of RNA with the length of 200 nucleotides. Unlike microRNAs, long non-coding RNAs can form secondary of tertiary domain based on their length. With the ability of directly interacting with DNA, RNA, protein, long non-coding RNAs have promoting or inhibitive functions in gene expression regulation. Furthermore, the abnormal expression of certain long non-coding RNAs ha...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2gP5gs3
via IFTTT