IJMS, Vol. 18, Pages 1547: Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer

IJMS, Vol. 18, Pages 1547: Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer

International Journal of Molecular Sciences doi: 10.3390/ijms18071547

Authors: Ingrid Garajová Manuela Ferracin Elisa Porcellini Andrea Palloni Francesca Abbati Guido Biasco Giovanni Brandi

The onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive biomarkers, could lead to an improvement in the success rate of the proposed therapies. Although the process of biomarker selection and validation could be a long one, requiring solid statistics, large cohorts and multicentric validations, non-coding RNAs (ncRNAs) and in particular microRNAs, proved to be extremely promising in this field. Here we summarize some of the main studies correlating specific ncRNAs with sensitivity/resistance to chemotherapy, anti-VEGF therapy, anti-EGFR therapy and immunotherapy in colorectal cancer (CRC).

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