HPV genotyping and p16 ÷Ki-67 dual staining in the detection of high-grade cervical lesion in patients with LSIL on Pap smear.

HPV genotyping and p16÷Ki-67 dual staining in the detection of high-grade cervical lesion in patients with LSIL on Pap smear. Rom J Morphol Embryol. 2017;58(2):433-437 Authors: Moleriu LC, Sas I, RaŢiu AC, Margan MM, Secoşan CA, Ilina RŞ, Horhat FG, Stana LG, Grigoraş D, Pirtea LC Abstract p16÷Ki-67 dual-stained cytology, either alone or combined with human papillomavirus (HPV) 16÷18 genotyping, could be a useful tool for triage for colposcopy of HPV-positive patients. Based on this background, we aimed at comparing the diagnostic performance of the p16÷Ki-67 dual staining test, and high-risk HPV test for the detection of high-risk cervical intraepithelial neoplasia (CIN2÷3) in patients diagnosed with low-grade squamous intraepithelial lesion (LSIL) on Pap sme...

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