Estrogen can restore Tamoxifen sensitivity in breast cancer cells amidst the complex network of resistance

Publication date: September 2017 Source:Biomedicine & Pharmacotherapy, Volume 93 Author(s): Sepideh Mansouri, Leila Farahmand, Aysooda Hosseinzade, Zahra Eslami-S, Keivan Majidzadeh-A Breast cancer-related deaths have been on the decline ever since the application of systemic therapies. Chiefly, endocrine therapy, such as Tamoxifen, enhances the survival of estrogen receptor (ER)-positive patients. More than a decade has passed since the introduction of Tamoxifen, however, drug resistance, particularly to Tamoxifen, still remains a major challenge. It has been shown that not only does chronic Tamoxifen exposures induce resistance, but estrogen deprivation can as well. There are two Tamoxifen resistant cell lines, long term estrogen deprived (LTED) cells and cells that have acquire...

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