Cis-drivers and trans-drivers of bovine leukemia virus oncogenesis

Publication date: October 2017 Source:Current Opinion in Virology, Volume 26 Author(s): Roghaiyeh Safari, Malik Hamaidia, Alix de Brogniez, Nicolas Gillet, Luc Willems The bovine leukemia virus (BLV) is a retrovirus inducing an asymptomatic and persistent infection in ruminants and leading in a minority of cases to the accumulation of B-lymphocytes (lymphocytosis, leukemia or lymphoma). Although the mechanisms of oncogenesis are still largely unknown, there is clear experimental evidence showing that BLV infection drastically modifies the pattern of gene expression of the host cell. This alteration of the transcriptome in infected B-lymphocytes results first, from a direct activity of viral proteins (i.e. transactivation of gene promoters, protein–protein interactions), second, from ins...

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