Association of thrombomodulin c.1418C>T polymorphism and venous thromboembolism

Publication date: 10 September 2017
Source:Gene, Volume 628
Author(s): Bei Hu, Qing-Yun Wang, Liang Tang, Yu Hu
ObjectivesTo investigate the association between thrombomodulin c.1418C>T polymorphism and venous thrombosis.MethodsSystematic searches of Pubmed, EMBASE, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, the VIP Database and WANFANG Database were performed. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. Subgroup analysis was conducted to seek for potential sources of heterogeneity.ResultsA total of 8 studies were collected in our analysis, including 2519 cases and 3196 controls. No significant association between thrombomodulin c.1418C>T polymorphism and venous thrombosis was shown under the five genetic models (T vs C: OR=1.02, 95% CI=0.82–1.26; TT vs CC: OR=0.90, 95% CI=0.52–1.56; CT vs CC: OR=1.07, 95% CI=0.84–1.37; CT+TT vs CC: OR=1.05, 95% CI=0.82–1.34; TT vs CT+CC: OR=0.81, 95% CI=0.59–1.11). Similar results were observed in the following subgroup analysis based on ethnicity and source of control. However, an increased risk of venous thrombosis was found in Asian populations under three genetic models (T vs C: OR=1.31, 95% CI=1.01–1.70; CT vs CC: OR=1.41, 95% CI=1.00–2.98; TT+CT vs CC vs CC: OR=1.41, 95% CI=1.02–1.95).ConclusionCurrent studies on the thrombomodulin c.1418C>T polymorphism are of great heterogeneity. It might not be a risk factor for venous thromboembolism.



from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2v7mvrs
via IFTTT