Scheduled meal accelerates entrainment to a 6 hours phase advance by shifting central and peripheral oscillations in rats.

Scheduled meal accelerates entrainment to a 6 hours phase advance by shifting central and peripheral oscillations in rats.

Eur J Neurosci. 2017 Jun 29;:

Authors: Ubaldo-Reyes LM, Buijs RM, Escobar C, Ángeles-Castellanos M

Abstract
Traveling across several time zones requires a fast adjustment of the circadian system and the differential adjustment speeds of organs and systems results in what is commonly referred as jet lag. During this transitory state of circadian disruption, individuals feel discomfort, appetite loss, fatigue, disturbed sleep and deficient performance of multiple tasks. We have demonstrated that after a 6-h phase advance of the light-dark cycle (LD) scheduled food in phase with the new night onset can speed up re-entrainment. In this study, we explored the possible mechanisms underlying the fast re-entrainment due to the feeding schedule. We focused on first and second order structures that provide metabolic information to the suprachiasmatic nucleus (SCN). We compared 1) control rats without change of LD cycle; 2) rats exposed to a 6 hours phase advance of the LD cycle with food ad libitum; and 3) rats exposed to the 6 hours phase advance combined with food access in phase with the new night. We found an immediate synchronizing effect of food on stomach distention and on c-Fos expression in the nucleus of the solitary tract, arcuate nucleus of the hypothalamus, dorsomedial hypothalamic nucleus and paraventricular nucleus. These observations indicate that in a model of jet lag, scheduled feeding can favor an immediate shift in first and second order relays to the SCN and that by keeping feeding schedules coupled to the new night, a fast re-entrainment may be achieved by shifting peripheral and extra-SCN oscillations. This article is protected by copyright. All rights reserved.

PMID: 28661071 [PubMed - as supplied by publisher]

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