Role of oxidative stress in liver cancer

Hossein Forouzandeh, Heibatullah Kalantari, Najmaldin Saki, Zahra Foruozandeh, Ehsan Arefian, Abbas Farahani, Ghasem Hassani, Mohammad Rafi Bazrafshan, Shima Rasouli

Clinical Cancer Investigation Journal 2017 6(1):1-9

The present article provides an overview of the role of oxidative stress in the development and progression of liver cancer (LC). Oxidative stress ensues when the balance between the production of reactive oxygen species (ROS) and reactive nitrogen species overrides the antioxidant defense of the target cell and body fails in detoxifying their harmful effects. Therefore, the interaction of these reactive species with critical cellular macromolecules may cause oxidative damage. Moreover, ROS may interact with cellular components including proteins, lipids, and DNAs, which results in altered target cell function. The accumulation of oxidative damage products has been implicated in both acute and chronic cell injury suggesting a possible role in the pathogenesis of Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, and cancers. Alcoholism, viral agents, obesity, and smoking increase the occurrence of oxidative stress and consequently the risk of LC.

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