Interleukin-10/lymphocyte ratio predicts mortality in severe septic patients

by Xi Li, Zhiheng Xu, Xiaoqing Pang, Yongbo Huang, Baoxin Yang, Yuanyuan Yang, Kangxie Chen, Xiaoqing Liu, Pu Mao, Yimin Li

Background

Immunosuppression is common even in the early stage of severe sepsis. Interleukin-10 (IL-10) secretion and lymphocyte exhaustion are the main features of sepsis-induced immunosuppression. However, the relationship between IL-10 and the lymphocyte is still unclear. We investigated if IL-10/lymphocyte ratio (IL10LCR) were associated with mortality in severe septic patients.

Methods

Adult patients with severe sepsis admitted to ICU of the First Affiliated Hospital of Guangzhou Medical University were identified from October 2012 to August 2013. Within 24 hours of ICU admission, peripheral whole blood was collected for the measurement of IL-10 using commercial multiplex bead-based assay kits and determination of lymphocyte count from laboratory data. The primary outcome was 28-day mortality.

Results

A total of 63 severe sepsis patients were identified. There were 20 (32%) patients died within 28 days. IL10LCR in non-survival patients was significantly higher than survival patients (median (IQR) 36.78 (12.34–79.63) ng/ml² versus 11.01(5.41–27.50) ng/ml², P = 0.002). Correlation analysis showed that IL10LCR was significantly correlated with APACHE II score (Spearman's rho = 0.424, P2, Kaplan-Meier curve showed survival in patients with IL10LCR level above 23.39ng/ml² was significantly lower than in patients with IL10LCR level less than 23.39ng/ml² (P = 0.001 by log-rank test).

Conclusion

IL10LCR level is significantly associated with the severity and outcome of severe septic patients. It may serve as a biomarker for sepsis-induced immunosuppression.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2sPtCXh
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