Impact of appropriateness of empiric therapy on outcomes in community-onset bacteremia by extended-spectrum- β-lactamase producing Escherichia coli and Klebisella pneumoniae definitively treated with carbapenems

AbstractDespite a significant increase of bloodstream infection caused by extended-spectrum- β-lactamase (ESBL)-producingEnterobacteriaceae in the community-setting, information regarding clinical outcomes of inappropriate empiric therapy (IAT) in patients with those infections is limited. A multicenter-retrospective cohort study was conducted in four hospitals. A total of 249 adults were identified to have community-onset bacteremia caused by ESBL-producingEscherichia coli andKlebsiella pneumoniae, and definitively treated with carbapenems. According to the appropriateness of empiric therapy, individuals were divided into an appropriate empiric therapy (AT) group (n = 106) and IAT group (n = 143). Patients who received AT showed more severe underlying conditions including underlying ...

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