Cetuximab ‐conjugated nanodiamonds drug delivery system for enhanced targeting therapy and 3D Raman imaging

In this study, a multicomponent nanodiamonds (NDs)‐based targeting drug delivery system, cetuximab‐NDs‐cisplatin bioconjugate, combining both specific targeting and enhanced therapeutic efficacy capabilities, is developed and characterized. The specific targeting ability of cetuximab‐NDs‐cisplatin system on human liver hepatocellular carcinoma (HepG2) cells is evaluated through epidermal growth factor receptor (EGFR) blocking experiments, since EGFR is over‐expressed on HepG2 cell membrane. Besides, cytotoxic evaluation confirms that cetuximab‐NDs‐cisplatin system could significantly inhibit the growth of HepG2 cells, and the therapeutic activity of this system is proven to be better than that of both nonspecific NDs‐cisplatin conjugate and specific EGF‐NDs‐cisplatin ...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2sp9fiP
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