Photooxidase‐mimicking nanovesicles with superior photocatalytic activity and stability based on amphiphilic amino acid and phthalocyanine co‐assembly

Enzyme mimics have broad applications in catalysis and can assist elucidation of the catalytic mechanism of natural enzymes. However, challenges arise from the design of catalytic sites, the selection of host molecules and their integration into active three‐dimensional structures. Herein, we develop a mimic photooxidase by synergetic molecular self‐assembly. 9‐Fluorenylmethyloxycarbonyl‐L‐histidine in combination with phthalocyanine shows efficient co‐assembly into nanovesicles with flexibly tunable particle size and membrane thickness. The obtained nanovesicles are capable of reactive oxygen‐mediated photosensitive oxidation with improved efficiency and stability. This work highlights the co‐assembly of simple building blocks into a supramolecular photocatalyst, which might give insight into possible evolutionary paths of photocatalytic membraneous systems and will allow the facile transfer into photosensitive nanoreactors or artificial organelles.

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