[ASAP] Temperature- and Mn2+ Concentration-Dependent Emission Properties of Mn2+-Doped ZnSe Nanocrystals

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b08480

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[ASAP] Coupled X-ray Absorption/UV–vis Monitoring of Fast Oxidation Reactions Involving a Nonheme Iron–Oxo Complex

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b08687

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[ASAP] Two-Dimensional Hybrid Perovskite-Type Ferroelectric for Highly Polarization-Sensitive Shortwave Photodetection

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12948

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[ASAP] Electron Paramagnetic Resonance Signature of Tetragonal Low Spin Iron(V)-Nitrido and -Oxo Complexes Derived from the Electronic Structure Analysis of Heme and Non-Heme Archetypes

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b11429

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[ASAP] Molecule Self-Assembly Synthesis of Porous Few-Layer Carbon Nitride for Highly Efficient Photoredox Catalysis

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12428

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[ASAP] Harnessing Alkylpyridinium Salts as Electrophiles in Deaminative Alkyl–Alkyl Cross-Couplings

Journal of the American Chemical Society

DOI: 10.1021/jacs.9b00111

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Black-hole jets begin to reveal their antimatter secrets

Black-hole jets begin to reveal their antimatter secrets

Black-hole jets begin to reveal their antimatter secrets, Published online: 30 January 2019; doi:10.1038/d41586-019-00347-y

The first simulations of matter and antimatter particles swirling around a rotating black hole hint at the origins of the enigmatic jets.

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Podcast: Women of the periodic table, and harvesting energy from Wi-Fi

Podcast: Women of the periodic table, and harvesting energy from Wi-Fi

Podcast: Women of the periodic table, and harvesting energy from Wi-Fi, Published online: 30 January 2019; doi:10.1038/d41586-019-00354-z

Hear the latest science news, brought to you by Benjamin Thompson and Noah Baker.

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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress, Published online: 30 January 2019; doi:10.1038/s41586-019-0895-y

Phosphorylation of one of two adjacent serine residues in TSC2 is both required and sufficient for PKG1-mediated cardiac protection against pressure overload in mice; these serine residues provide a genetic tool for the bidirectional regulation of stress-stimulated mTORC1 activity.

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How to write effectively for international journals

How to write effectively for international journals

How to write effectively for international journals, Published online: 30 January 2019; doi:10.1038/d41586-019-00359-8

Use modern tools to manage research literature, analyse published articles and find language teachers to improve manuscripts for publication.

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Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution, Published online: 30 January 2019; doi:10.1038/s41586-019-0887-y

Repeated selection for adaptive mutations in a diploid yeast model results in increased genetic instability and sheds light on mechanisms of genetic instability that might contribute to tumorigenesis.

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Age estimates for hominin fossils and the onset of the Upper Palaeolithic at Denisova Cave

Age estimates for hominin fossils and the onset of the Upper Palaeolithic at Denisova Cave

Age estimates for hominin fossils and the onset of the Upper Palaeolithic at Denisova Cave, Published online: 30 January 2019; doi:10.1038/s41586-018-0870-z

Bayesian modelling of chronometric, stratigraphic and genetic data from Denisova Cave provides a chronological framework for understanding Neanderthal and Denisovan presence at the site, as well as interactions between these groups.

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Timing of archaic hominin occupation of Denisova Cave in southern Siberia

Timing of archaic hominin occupation of Denisova Cave in southern Siberia

Timing of archaic hominin occupation of Denisova Cave in southern Siberia, Published online: 30 January 2019; doi:10.1038/s41586-018-0843-2

Optical dating of sediments from Denisova Cave establishes a chronology for its Pleistocene deposits and the associated artefacts, hominin remains and environmental records, which date to between about 300,000 and 20,000 years ago.

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Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H2

Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H₂

Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H₂, Published online: 30 January 2019; doi:10.1038/s41586-018-0869-5

Atomically dispersed iron hydroxide deposited on silica-supported platinum nanoparticles enables complete and selective carbon monoxide removal through preferential oxidation in hydrogen in the temperature range from 198 to 380 kelvin.

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Secondary organic aerosol reduced by mixture of atmospheric vapours

Secondary organic aerosol reduced by mixture of atmospheric vapours

Secondary organic aerosol reduced by mixture of atmospheric vapours, Published online: 30 January 2019; doi:10.1038/s41586-018-0871-y

Adding reactive gases such as isoprene to mixtures lowers the production of secondary organic aerosol in the atmosphere, thus reducing the atmospheric particulate burden, with implications for human health and climate.

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Dating of hominin discoveries at Denisova

Dating of hominin discoveries at Denisova

Dating of hominin discoveries at Denisova, Published online: 30 January 2019; doi:10.1038/d41586-019-00264-0

Denisova Cave sheltered hominins at least 200,000 years ago, and excavations there have illuminated our understanding of early hominins in Asia. New dating analyses now refine this knowledge.

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One rogue agent suffices for genomic chaos

One rogue agent suffices for genomic chaos

One rogue agent suffices for genomic chaos, Published online: 30 January 2019; doi:10.1038/d41586-019-00260-4

Genetic instability is a hallmark of cancer cells, and occurs when genes required for genomic maintenance are inactivated. It emerges that altering just one of the two copies of certain genes can drive genetic instability in yeast.

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Deacylative transformations of ketones via aromatization-promoted C–C bond activation

Deacylative transformations of ketones via aromatization-promoted C–C bond activation

Deacylative transformations of ketones via aromatization-promoted C–C bond activation, Published online: 30 January 2019; doi:10.1038/s41586-019-0926-8

Deacylative transformations of ketones via aromatization-promoted C–C bond activation

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Complex networks reveal global pattern of extreme-rainfall teleconnections

Complex networks reveal global pattern of extreme-rainfall teleconnections

Complex networks reveal global pattern of extreme-rainfall teleconnections, Published online: 30 January 2019; doi:10.1038/s41586-018-0872-x

Complex networks are used to analyse global-scale teleconnections between extreme-rainfall events, revealing a peak in the distance distribution of statistically significant connections at around 10,000 kilometres.

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A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses, Published online: 30 January 2019; doi:10.1038/s41586-019-0898-8

An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

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Experimentally trained statistical models boost nuclear-fusion performance

Experimentally trained statistical models boost nuclear-fusion performance

Experimentally trained statistical models boost nuclear-fusion performance, Published online: 30 January 2019; doi:10.1038/d41586-019-00261-3

Research into a technique called inertial confinement fusion aims to enhance nuclear-fusion performance in laboratory experiments. Improvements in the technique have been made using a clever statistical approach.

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Atmospheric reaction networks affecting climate are more complex than was thought

Atmospheric reaction networks affecting climate are more complex than was thought

Atmospheric reaction networks affecting climate are more complex than was thought, Published online: 30 January 2019; doi:10.1038/d41586-019-00263-1

Experiments show that the amount of atmospheric particles produced from plant emissions could be lower than was thought — challenging our understanding of the processes that affect air quality and climate.

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Interleukin-22 protects intestinal stem cells against genotoxic stress

Interleukin-22 protects intestinal stem cells against genotoxic stress

Interleukin-22 protects intestinal stem cells against genotoxic stress, Published online: 30 January 2019; doi:10.1038/s41586-019-0899-7

Sporadic inactivation of the interleukin-22 receptor in the intestinal epithelium of the mouse shows that IL-22 is required for effective activation of the DNA damage response following DNA damage.

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What Makes a ‘Super’ Fecal Donor Could Be in Their Genetics, Diet

Keystone species, host-genetics and diet may all play a role in "super donors"—who elevate FMT success rates, according to a new study published in Frontiers. Fecal transplants in patients with Clostridium difficile infections, or diarrheal infections, show to have a 91 percent success rate with FMT, yet chronic conditions such as Alzheimer's, multiple sclerosis, cancer, asthma, allergies and heart disease do not always have similar outcomes. (The fecal transplantation success rate for inf...

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New Technology Gives Unprecedented Look Inside Capillaries

Now a Northwestern University team has developed a new tool that images blood flow through these tiny vessels, giving insight into this central portion of the human circulatory system. Called spectral contrast optical coherence tomography angiography (SC-OCTA), the 3-D-imaging technique can detect subtle changes in capillary organization for early diagnosis of disease. "There has been a progressive push to image smaller and smaller blood vessels and provide more comprehensive, functional i...

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New Technology Gives Unprecedented Look Inside Capillaries

Now a Northwestern University team has developed a new tool that images blood flow through these tiny vessels, giving insight into this central portion of the human circulatory system. Called spectral contrast optical coherence tomography angiography (SC-OCTA), the 3-D-imaging technique can detect subtle changes in capillary organization for early diagnosis of disease. "There has been a progressive push to image smaller and smaller blood vessels and provide more comprehensive, functional i...

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Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations

Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations

Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations, Published online: 30 January 2019; doi:10.1038/s41467-018-07983-4

It is unclear whether the sequence and timing of early life neurodevelopment varies across human populations, excluding the effects of disease or malnutrition. Here, the authors show that children of healthy, urban, educated mothers show very similar development across five geographically diverse populations.

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Next-generation muscle-directed gene therapy by in silico vector design

Next-generation muscle-directed gene therapy by in silico vector design

Next-generation muscle-directed gene therapy by in silico vector design, Published online: 30 January 2019; doi:10.1038/s41467-018-08283-7

Adeno-associated viral vectors (AAV) are being developed for gene therapy of skeletal muscle, but it is a challenge to achieve robust gene expression. Here, the authors identify muscle-specific cisregulatory elements that lead to a substantial increase in micro-dystrophin and follistatin expression, resulting in a safe and sustainable rescue of the dystrophic phenotype in mouse models.

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The path of pre-ribosomes through the nuclear pore complex revealed by electron tomography

The path of pre-ribosomes through the nuclear pore complex revealed by electron tomography

The path of pre-ribosomes through the nuclear pore complex revealed by electron tomography, Published online: 30 January 2019; doi:10.1038/s41467-019-08342-7

Large protein complexes and ribonucleoprotein particles (RNPs) such as pre-ribosomes are transported from the nucleus to the cytoplasm through the nuclear pore complex (NPC). Here the authors use ultrafast freezing and electron tomography to catch snapshots of native RNPs crossing the NPC and estimate their transit time using a probabilistic model.

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Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis, Published online: 30 January 2019; doi:10.1038/s41467-019-08387-8

Lineage segregation from conception to gastrulation has been mapped at the single cell level in mouse, human and monkey. Here, the authors provide a comprehensive analysis of porcine preimplantation development using single cell RNA-seq; mapping metabolic changes, X chromosome inactivation and signalling pathways.

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Enhanced strength–ductility synergy in ultrafine-grained eutectic high-entropy alloys by inheriting microstructural lamellae

Enhanced strength–ductility synergy in ultrafine-grained eutectic high-entropy alloys by inheriting microstructural lamellae

Enhanced strength–ductility synergy in ultrafine-grained eutectic high-entropy alloys by inheriting microstructural lamellae, Published online: 30 January 2019; doi:10.1038/s41467-019-08460-2

Producing in situ composite materials with superior strength and ductility has long been a challenge. Here, the authors use lamellar microstructure inherited from casting, rolling, and annealing to produce an ultrafine duplex eutectic high entropy alloy with outstanding properties.

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Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells, Published online: 30 January 2019; doi:10.1038/s41467-019-08378-9

The precise cellular patterning and decisions of early embryogenesis have been hard to mimic in vitro. Here, the authors culture murine embryonic and trophoblast stem cells together with extra-embryonic endoderm stem cells to form embryo-like structures (ETX-embryoids), which can initiate an implantation response.

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Caution in inferring viral strategies from abundance correlations in marine metagenomes

Caution in inferring viral strategies from abundance correlations in marine metagenomes

Caution in inferring viral strategies from abundance correlations in marine metagenomes, Published online: 30 January 2019; doi:10.1038/s41467-018-07950-z

Caution in inferring viral strategies from abundance correlations in marine metagenomes

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Impact of Peritoneal Metastasis on Survival of Patients With Small Intestinal Neuroendocrine Tumor

The liver and peritoneum are the 2 most common distant metastatic sites for small intestinal neuroendocrine tumors (SI-NET). In this study, we evaluated the differential impact of hepatic and/or peritoneal metastasis on prognosis of SI-NET patients. Surgical Pathology archives were searched for SI-NET resections performed between January 1, 1994 and August 31, 2017. Two hundred nineteen cases with clinical follow-up data were identified. Pathology reports and electronic medical records were reviewed. The 219 patients included 104 females and 115 males with a median age of 59 years (range, 19 to 85 y). There were 71 (33%) cases without hepatic or peritoneal metastasis, 80 (37%) with hepatic metastasis only, 14 (6%) with peritoneal metastasis only, and 53 (24%) with both hepatic and peritoneal metastasis at the time of surgery or during follow-up. The number of primary tumors, largest tumor size, lymph node metastasis, pT category, and sex were not significant independent prognostic factors in multivariate Cox proportional hazard regression. Age was the only variable other than presence of metastatic disease that was associated with worse prognosis (5% increase in risk/year of age; 95% confidence interval, 1.7%-8.2%; P=0.003). After controlling for patient age, pairwise comparisons of marginal linear predictions showed increased risk with peritoneal metastasis, with or without associated hepatic metastasis, compared to hepatic metastasis only. In conclusion, although limited by the number of patients with peritoneal metastasis only, these results support substratifying patients with metastatic SI-NET by anatomic site of metastasis. Conflicts of Interest and Source of Funding: Supported by NIH/NIDDK 5P30 DK058404-13 (C.S.) and NIH/NCI 5P50 CA095103-13 (C.S.). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Correspondence: Chanjuan Shi, MD, PhD, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, C-3321 MCN, Nashville, TN 37232-2561 (e-mail: chanjuan.shi@vanderbilt.edu). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

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How to write effectively for international journals

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Towards more effective and transferable transition experiments: learning through stratification

Abstract

We argue that the increasing use of experimental approaches in transition and transformational research on potential sustainability solutions could substantially profit from application of the principles of stratification and stratified experimental design. We illustrate our proposition with three worked examples of hypothetical transition experiments and argue that the use of stratification can produce three essential benefits in transition experiments: (1) increased methodological validity and better comparability of experimental results, (2) potential scalability of sustainability solutions tested, and (3) better assessment of potential transferability of sustainability solutions to other systems. Moreover, stratification and stratified design of transition experiments might be employed to address some of the recently raised criticisms regarding reproducibility of results and the appropriate use of statistical methodology in scientific experimentation in general and transition experimentation in particular.

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Far-flung volcanoes’ surprising climate role

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The path of pre-ribosomes through the nuclear pore complex revealed by electron tomography

from A via a.sfakia on Inoreader https://go.nature.com/2BeNYw9

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

from A via a.sfakia on Inoreader https://go.nature.com/2Tml9Ff