Catalytic Biomimetic Asymmetric Reduction of Alkenes and Imines Enabled by Chiral and Regenerable NAD(P)H Models

The development of biomimetic chemistry based on the NAD(P)H with hydrogen gas as terminal reductant is a long‐standing challenge. Through rational design of the chiral and regenerable NAD(P)H models based on planar chiral ferrocene skeleton, a biomimetic asymmetric reduction has been realized using bench‐stable Lewis acids as transfer catalysts, a broad set of alkenes and imines could be reduced with up to 98% yield and 98% ee, likely enabled by enzyme‐like cooperative bifunctional activation. This represents the first general biomimetic asymmetric reduction (BMAR) process enabled by chiral and regenerable NAD(P)H models. This concept demonstrates catalytic utility of chiral coenzyme NAD(P)H in asymmetric catalysis.

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