Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane [Biophysics and Computational Biology]

Lipidated small GTPases and their regulators need to bind to membranes to propagate actions in the cell, but an integrated understanding of how the lipid bilayer exerts its effect has remained elusive. Here we focused on ADP ribosylation factor (Arf) GTPases, which orchestrate a variety of regulatory functions in lipid...

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