MiR-103 Functions as a Tumor Suppressor by Directly Targeting Programmed Cell Death 10 in NSCLC.

Authors: Yang D, Wang JJ, Li JS, Xu QY Abstract NSCLC accounts for about 85% of all lung cancer cases. Absence of miR-103 has recently identified to be associated withmetastatic capacity of primary lung tumors. However, the exact role of miR-103 in NSCLC and the molecular mechanism is unclear. In the present study, we showed that miR-103 expression was reduced in NSCLC tissues and cells. miR-103 expression was negatively correlated with tumor size and stage. The overall survival was longer in patients with higher miR-103 level than in those with lower miR-103 expression. miR-103 inhibited cell proliferation in A549 cells, decreased tumor weight and volume and prolonged survival of tumor-implanted nude mice. miR-103 increased apoptotic cell death A549 cells. Furthermore, miR-103 dec...

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