MicroRNA-374a Promotes Hepatocellular Carcinoma Cell Proliferation by Targeting Mitogen-Inducible Gene-6 (MIG-6).

This study was aimed to investigate the role of miR-374a in HCC and its role in regulation of expression of MIG-6. The results showed that MIG-6 overexpression significantly inhibited cell viability of HepG2 cells after 4 day of post-transfection. Moreover, MIG-6 was a direct target of miR-374a and the expression of MIG-6 was remarkably down-regulated by overexpression of miR-374a in HepG2 cells. Furthermore, we found that overexpression of miR-374a promoted cell viability, however, the protective effect was abolished by MIG-6 overexpression. Besides, overexpression of miR-374a activated EGFR and AKT/ERK signal pathways by regulation of MIG-6. Our findings suggest that miR-374a could promote cell viability by targeting MIG-6 and activating EGFR and AKT/ERK signal pathways. These data will ...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2vAAVRt
via IFTTT