Association between age ‐related reductions in testosterone and risk of prostate cancer—An analysis of patients' data with prostatic diseases

The relationship between serum total testosterone and prostate cancer (PCa) risk is controversial. The hypothesis that faster age‐related reduction in testosterone is linked with increased PCa risk remains untested. We conducted our study at a tertiary‐level hospital in southeast of the USA, and derived data from the Medical Registry Database of individuals that were diagnosed of any prostate‐related disease from 2001 to 2015. Cases were those diagnosed of PCa and had one or more measurements of testosterone prior to PCa diagnosis. Controls were those without PCa and had one or more testosterone measurements. Multivariable logistic regression models for PCa risk of absolute levels (one‐time measure and 5‐year average) and annual change in testosterone were respectively constructe...

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