OTX1 and OTX2 genes in medulloblastomas.

OTX1 and OTX2 genes in medulloblastomas.

World Neurosurg. 2019 Feb 21;:

Authors: Figueira Muoio VM, Uno M, Oba-Shinjo S, da Silva R, Araújo Pereira BJ, Clara C, Matushita H, Marie SNK

Abstract
OBJECTIVES: To study the prevalence of OTX1 and OTX2 gene expression in 60 medulloblastoma specimen samples, and to establish correlations between gene expression and clinical and histopathological aspects.
CASUISTICS AND METHODS: A retrospective analysis of 60 patients, diagnosed with medulloblastoma at the Clinicas Hospital of the School of Medicine, University of São Paulo, and the Cancer Hospital of Barretos, was conducted. A database of 60 patients containing information on the gene expression of OTX1 and OTX2 genes (obtained by real-time PCR) and clinical and epidemiological data was created. Statistical tests were performed to verify potential correlation of clinical-pathological and follow-up aspects with gene expression.
RESULTS: The OTX1 gene was expressed in 52% of the study population. Expression varied with age (higher in adults), location (predominantly by hemisphere) and histology (desmoplastic). The OTX2 gene was expressed in 62% of the study population. Expression varied with age (higher in younger age groups), location (predominantly vermis) and histological type (classic and anaplastic). A statistical correlation between the expression of the OTX2 gene and development of leptomeningeal metastases was observed.
CONCLUSIONS: Relative expressions of OTX1 and OTX2 were dependent on patient age, tumor location and histological variant, while OTX2 expression level may be a predictive factor for leptomeningeal metastases of medulloblastoma. The OTX pathway should be consider as an important venue for medulloblastomas development.

PMID: 30797919 [PubMed - as supplied by publisher]

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