Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer, Published online: 13 February 2019; doi:10.1038/s41467-019-08586-3

Whether the Wnt enhanceosome' components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.

from A via a.sfakia on Inoreader https://go.nature.com/2N4Uqun