Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis, Published online: 28 January 2019; doi:10.1038/s41467-019-08411-x

The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.

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