CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers, Published online: 14 December 2018; doi:10.1038/s41467-018-07653-5

The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.

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