One-stage and two-stage meta-analysis of individual participant data led to consistent summarized evidence: lessons learned from combining multiple databases

Combining multiple healthcare databases allows comparing the effects of a wide variety of healthcare services. There is a growing interest in methods for combining the results from multiple databases. We attempted to learn lessons about the performance of one-stage and two-stage approaches from the re-analysis of data drawn from two studies of pharmacoepidemiology based on multiple databases.

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