We read with interest the WOMAN trial1 and commend the investigators on this important multicentre, international, placebo-controlled trial. For a study to have external validity, its conditions need to be representative of a larger population. This study was mainly done in low-income and middle-income countries; thus, we have concerns about its generalisability. Many differences probably exist in the health-care systems (and disease burdens) between many countries included in the trial. Therefore, we do not think the results are immediately translatable to high-income countries.
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,