The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps.

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The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps.

J Laryngol Otol. 2017 Aug 15;:1-9

Authors: Zhao QL, Yu L, Zhi LL, Jin P, Zi XX, Zhao L, Li A, Tu YY, Shi L, Zhang HP

Abstract
OBJECTIVE: To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features.
METHODS: The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling.
RESULTS: Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (p < 0.05) in epithelial hyperplasia, and predicted maximal expiratory flow rate at 50 per cent vital capacity was reduced (p < 0.05) in goblet cell hyperplasia. Both peripheral blood eosinophilia and tissue eosinophilia nasal polyps manifested significantly reduced: forced expiratory volume in 1 second/forced vital capacity ratio, predicted maximal expiratory flow rate at 25, 50 and 75 per cent of vital capacity, and predicted maximal mid-expiratory flow. Peripheral blood eosinophils were negatively correlated with predicted maximal expiratory flow rate at 25 and 50 per cent of vital capacity, and predicted maximal mid-expiratory flow. Eosinophils in tissue were negatively correlated with all lung function parameters investigated except predicted forced vital capacity.
CONCLUSION: Clinicians should be aware of lung function decline in nasal polyps patients, especially in those with tissue eosinophilia.

PMID: 28807078 [PubMed - as supplied by publisher]

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