Modulation of inflammatory and immune responses by vitamin D.

Authors: Colotta F, Jansson B, Bonelli F Abstract Vitamin D (VitD) is a prohormone most noted for the regulation of calcium and phosphate levels in circulation, and thus of bone metabolism. Inflammatory and immune cells not only convert inactive VitD metabolites into calcitriol, the active form of VitD, but also express the nuclear receptor of VitD that modulates differentiation, activation and proliferation of these cells. In vitro, calcitriol upregulates different anti-inflammatory pathways and downregulates molecules that activate immune and inflammatory cells. Administration of VitD has beneficial effects in a number of experimental models of autoimmune disease. Epidemiologic studies have indicated that VitD insufficiency is frequently associated with immune disorders and infe...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2vRdKBB
via IFTTT