IL-17 Promotes Differentiation of Splenic LSK(-) Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection.

Authors: Ghosh D, Brown SL, Stumhofer JS Abstract Lineage(-)Sca-1(+)c-Kit(-) (LSK(-)) cells are a lymphoid progenitor population that expands in the spleen and preferentially differentiates into mature B cells in response to Plasmodium yoelii infection in mice. Furthermore, LSK(-) derived B cells can subsequently contribute to the ongoing immune response through the generation of parasite-specific Ab-secreting cells, as well as germinal center and memory B cells. However, the factors that promote their differentiation into B cells in the spleen postinfection are not defined. In this article, we show that LSK(-) cells produce the cytokine IL-17 in response to Plasmodium infection. Using Il-17ra(-/-) mice, IL-17R signaling in cells other than LSK(-) cells was found to support their d...

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