GSE98689 MicroRNAs-143 and -145 induce epithelial to mesenchymal transition by enhancing TGF- β signaling and modulating the expression of junction proteins

Contributors : Lidia Avalle ; Danny Incarnato ; Aurora Savino ; Marta Gai ; Francesca Marino ; Sara Pensa ; Isaia Barbieri ; Michael B Stadler ; Paolo Provero ; Salvatore Oliviero ; Valeria PoliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTransforming growth factor (TGF)- β is one of the major inducers of epithelial to mesenchymal transition (EMT), a crucial program that plays a critical role in promoting carcinoma's metastasis formation. MicroRNAs-143 and -145, which are both TGF-β direct transcriptional targets, are essential for the differentiation of vascular smooth muscle cells (VSMC) during embryogenesis, a TGF-β-dependent process reminiscent of EMT. Their role in adult tissues is however less well defined and even ambiguous, since their...

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