GSE101584 Tumor-associated neutrophils display a distinct N1 profile following TGF β modulation: A transcriptomics analysis of pro- vs. antitumor TANs

Contributors : Merav E Shaul ; Liran Levy ; Jing Sun ; Inbal Mishalian ; Sunil Singhal ; Veena Kapoor ; Wenhwai Horng ; Gil Fridlender ; Steven M Albelda ; Zvi G FridlenderSeries Type : Expression profiling by arrayOrganism : Mus musculusIt is becoming increasingly clear that tumor-associated neutrophils (TANs) play an important role in cancer biology, through direct impact on tumor growth and by recruitment of other cells types into the tumor. The function of neutrophils in cancer has been the subject of seemingly contradicting reports, pointing toward a dual role played by TANs in tumor progression. The existence of multiple neutrophil subsets, as well as phenotypic modulation of the neutrophils by various factors in the tumor microenvironment, has been shown. TGF β plays a significant ...

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