Odontogenic Potential of Parathyroid Hormone–related Protein (107-111) Alone or in Combination with Mineral Trioxide Aggregate in Human Dental Pulp Cells

Parathyroid hormone–related protein plays an important role in bone remodeling. Its N-terminal domain parathyroid hormone–related protein (107-111) is called osteostatin (OST). OST has demonstrated osteogenic potential when combined with biomaterials such as hydroxyapatite or bioceramics. However, the odontogenic potential of OST has not yet been reported. Therefore, the aim of this study was to determine whether OST has an odontogenic effect or a synergistic effect with mineral trioxide aggregate (MTA) in human dental pulp cells (hDPCs) and to examine the underlying signaling mechanisms involved in OST-mediated odontogenic differentiation.

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