Effective treatment of Restless Legs Syndrome by Safinamide in Parkinson’s Disease patients

Parkinson's Disease (PD) is often associated with insomnia, REM sleep behavior disorder, sleep-related breathing disorders and restless legs syndrome (RLS).1 Safinamide is a monoaminoxidase-B inhibitor (IMAO-B) approved as add-on therapy to levodopa (LD) in PD.2 Here, we report two cases of motor fluctuating PD patients, who experienced the improvement of RLS symptoms after starting Safinamide as add-on to LD.

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