CDK4/6 inhibition in early and metastatic breast cancer: a review

Breast cancer (BC) continues to be a major health problem for women around the world, with almost 1.7 million new cases diagnosed annually worldwide, causing an estimated 500.000 deaths every year. [2] Despite the fact that the overall 5-year survival has increased to 90%, metastatic disease remains incurable with an estimated 5-year survival rate of only 25%. [3]

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