Protamine neutralizes CSPG-mediated inhibition of oligodendrocyte differentiation

(National Institutes of Natural Sciences) The research group of researcher Akihiro Fujikawa and Professor Masaharu Noda of the National Institute for Basic Biology developed a screening method to obtain neutralizing agents for canceling the inhibitory effects of CSPGs on oligodendrocyte differentiation. The group found that the inhibitory activity of a representative extracellular matrix CSPG molecule, aggrecan, was neutralized by a polycationic peptide, protamine, that is clinically used to stop the anticoagulant effect of heparin. (Source: EurekAlert! - Cancer)

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