Determination of MIC and Disk Diffusion Quality Control Guidelines for Meropenem-vaborbactam, a Novel Carbapenem/Boronic Acid β-lactamase Inhibitor Combination

Publication date: Available online 5 December 2017
Source:Diagnostic Microbiology and Infectious Disease
Author(s): Erik Munson, Michael D. Huband, Mariana Castanheira, Kelley A. Fedler, Robert K. Flamm
Meropenem-vaborbactam is a carbapenem/cyclic boronic acid β-lactamase inhibitor combination primarily active against Gram-negative bacilli, including those harboring class A serine carbapenemases such as Klebsiella pneumoniae carbapenemase (KPC). A CLSI M23-A4 (tier-2) quality control study established broth microdilution and disk diffusion ranges for reference strains. Two KPC-producing K. pneumoniae ATCC strains are recommended for quality control testing.



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