[Correspondence] Diagnostic algorithm for low-volume CSF samples in tuberculous meningitis

Nathan Bahr and colleagues1 reported the diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults. They report significantly high sensitivity of Xpert-Ultra (95%) versus Xpert (45%), which was similar to Mycobacteria Growth Indicator Tube (MGIT) culture. The authors also show that no test is 100% accurate, and even Xpert-Ultra can miss or give indeterminate results in culture-positive cases.

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