IGF system targeted therapy: therapeutic opportunities for ovarian cancer

Ovarian cancer has the highest mortality rate of all gynecological tumors, due to the late onset of symptoms. It represents the fifth leading cause of cancer-related death in American and European women[1]. Most ovarian carcinomas are of epithelial origin (90%) and can be classified into four major histological subtypes, which include serous (70%), endometrioid (10-15%), mucinous (10%) and clear cell (5%). Although these subtypes represent clinically different entities, all patients receive standard treatment consisting of cytoreductive surgery followed by a combination of platinum- and taxane-based chemotherapy.

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