Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load [Biophysics and Computational Biology]

Homodimeric KIF17 and heterotrimeric KIF3AB are processive, kinesin-2 family motors that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along microtubules (MTs) toward the tips of cilia. How IFT trains attain speeds that exceed the unloaded rate of the slower, KIF3AB motor remains unknown. By characterizing the...

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