Topoisomerase I deregulation in laryngeal squamous cell carcinomas based on tissue microarray analysis.

CONCLUSIONS: Topo I overexpression is observed in a significant subset of LSCCs affecting the level of differentiation in them. Additional molecular studies focused on the mechanism of Topo I gene/protein deregulation (i.e. amplification, abnormal epigenetic promoter methylation, mRNA aberrant expression) are necessary discriminating the eligible patients for applying specific chemotherapeutic strategies based on anti-Topo I agents. PMID: 28730788 [PubMed - in process] (Source: Journal of B.U.ON.)

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