Inflammatory Mediators Mediate Airway Smooth Muscle Contraction through a GPCR-TMEM16A-VDCC Axis and Contribute to Bronchial Hyperresponsiveness in Asthma

The GPCR-TMEM16A-VDCC signalling axis plays important role in inflammatory mediator-induced ASM contraction and hypersensitivity. TMEM16A may be a prospective drug target of asthma.

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