GSE101745 FGF-13 promotes metastasis in triple-negative breast cancer

Contributors : Andrew D Pattison ; Paul F Harrison ; David R Powell ; Traude H BeilharzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo define the molecular regulators of metastasis of triple-negative breast cancer, we conducted a rigorous characterization of four isogenic populations of MDA-MB-231 human triple-negative breast cancer cells that display a range of intrinsic spontaneous metastatic capacities in immuno-deficient mice, from non-metastatic to highly metastatic to lung, liver, spleen and spine. PAT-Seq gene expression profiling of primary tumor cells identified the fibroblast growth factor homologous factor, FGF13, as a candidate metastatic virulence gene highly upregulated in aggressively metastatic MDA-MB-231HM tumors. (Source: GEO: Gen...

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