Dual organ beneficial effects of metformin in cirrhotic rats with hepatopulmonary syndrome

Liver fibrosis causes portal hypertension which dilates collateral vasculature and enhances extra-hepatic angiogenesis including intrapulmonary shunts, which subsequently complicates with hepatopulmonary syndrome (HPS). Metformin is an anti-diabetic agent which has anti-inflammation and anti-angiogenesis properties.1–3 HPS is a severe complication of liver cirrhosis which is characterized by deoxygenation in cirrhotic patients.4 In this issue of the Journal of the Chinese Medical Association, Chen and his colleagues comprehensively evaluated the hemodynamic and biochemistry parameters, and a blood-gas analysis of a 21-day regimen of metformin 150 mg/kg/day treatment on common bile duct ligated (CBDL)-cirrhotic rats.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2sYvlL1
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