Assessment of intervention-related changes in non-rapid-eye-movement sleep depth: importance of sleep depth changes within stage 2

Depth of sleep within non-rapid-eye-movement (non-REM) stage-2 (N2-depth) varies from being nearly similar to stage-1 to nearly similar to stage-3. Differences in N2-depth are not captured by conventional indices of sleep depth (N1–N3 times, arousal/awakening index) when comparing sleep depth under different conditions. Magnitude of changes in N2-depth in the same individual under different experimental conditions, and the importance of measuring these changes are unknown.

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